临床前研究 · 泰州医药城
Preclinical Research · Taizhou Medical High-Tech Zone

守护人与动物的健康 Advancing Health forHumans & Animals

健优达生物医药科技有限公司——专业从事 SPF 级实验动物培育与疾病模型建立，助力新药研发与兽医生物技术创新。

Taizhou Jianyouda Biomedical Technology Co., Ltd. — specializing in SPF laboratory animal breeding and disease model development to advance drug discovery and veterinary biotechnology.

1000+ SPF 猫种群 SPF Cat Colony
150+ 比格犬种群 Beagle Colony
5000 ㎡ Facility

诚信 · 创新 · 责任 · 共赢

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Our Corporate Values

企业核心价值观

01 — ABOUT

关于我们

About Us

健优达生物医药科技有限公司成立于 2021 年，坐落于中国泰州医药城，现有设施 5000 ㎡。设施内配有动物饮水处理系统、环境控制系统，以及高压灭菌设备、动物麻醉机等专业设备。

公司主要从事实验动物 SPF 级猫及 SPF 级犬的培育。拥有一支来自知名药企的博士、硕士组成的技术团队，致力于不同种属（犬、猫、猪）等实验模型建立，以人用新药/兽用药物/疫苗检测为特色的临床前安全性和有效性评价研究。为多家知名企业提供临床前相关服务，为人与动物健康保驾护航。

Jianyouda Biomedical Technology Co., Ltd. was established in 2021 and is located in China Medical City, Medical High-tech Zone. Jianyouda operates a modern animal research facility with a total area of 5,000 m², equipped with advanced infrastructure including animal water purification systems, environmental control systems, high-pressure sterilization units, and small-animal anesthesia equipment.

The company specializes in breeding SPF (Specific Pathogen-Free) cats and dogs. It is supported by a technical team composed of Ph.D.s and master's degree holders from renowned pharmaceutical companies, dedicated to establishing experimental models across various species—including dogs, cats, and pigs—with a focus on preclinical safety and efficacy evaluation studies for human pharmaceuticals, veterinary drugs, and vaccines. The company provides preclinical services to numerous well-known enterprises, contributing to the health and well-being of both humans and animals.

🏛️
北京健优达生物医药科技有限公司 Beijing Jianyouda Biomedical Technology Co., Ltd. 取得实验动物生产资质 Licensed for Experimental Animal Production
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泰州建达医药科技有限公司 Taizhou Jianda Pharmaceutical Technology Co., Ltd. 取得BSL-2与 ABSL-2 相关资质 Obtained BSL-2 and ABSL-2 related certifications/accreditations.
诚
诚信
Integrity
以诚信为本，建立长久合作关系
Building lasting partnerships with honesty
创
创新
Innovation
持续推动科学研究方法创新
Continuously advancing scientific methods
责
责任
Responsibility
对科学、动物与社会负责
Committed to science, animals and society
赢
共赢
Win-Win
与客户携手共同实现价值
Creating shared value with every partner
02 — PRODUCTS

产品中心

Our Products

SPF 级实验猫
SPF Laboratory Cats
Specific Pathogen Free
1000+ 种猫数量 Breeding Colony
200+ 月生产量（2–3 月龄） Monthly Output (2–3 months)
稳定的遗传背景与标准化健康监测
Stable genetic background and standardized health monitoring
病毒学与疫苗评价、神经科学与行为生理学研究、呼吸系统与心血管药理、消化系统疾病与口腔医学等
Suitable for dermatitis, FIP, osteoarthritis disease models
SPF 级实验犬
SPF Laboratory Dogs
Beagle — Specific Pathogen Free
150+ 比格犬种群数量 Beagle Colony Size
50+ 月生产量（2–3 月龄） Monthly Output (2–3 months)
标准化 SPF 条件下培育与管理
Bred and managed under standardized SPF conditions
适用于药代、药效及安全性评价研究
Suitable for PK/PD and safety evaluation studies
经验丰富的兽医团队全程监护
Monitored by experienced veterinary team
03 — DISEASE MODELS

疾病模型平台

Disease Model Platform

01
猫特应性皮肤综合征（特异性皮炎）
Feline Atopic Skin Syndrome (Atopic Dermatitis)
Allergic Dermatitis Model
由环境过敏原（尘螨、霉菌、花粉等）引起的猫过敏性皮肤病，免疫球蛋白 E 抗体可能参与其中。表现为头部/颈部瘙痒、粟粒性皮炎、自我诱导性对称性脱毛及嗜酸性肉芽肿复合征四种经典模式，通常 3 岁前首次出现症状。
An allergic skin condition triggered by environmental allergens (dust mites, mold, pollen) in cats, potentially involving IgE antibodies. Presents as four classical patterns: head/neck pruritus, miliary dermatitis, self-induced symmetric alopecia, and eosinophilic granuloma complex. Symptoms typically appear before age 3.
Anti-allergy Anti-inflammatory Immunotherapy Dermatology
临床表现
Clinical Signs
头颈部瘙痒抓伤、背部粟粒性结痂丘疹、腹部对称性脱毛、下唇无痛性溃疡及腺肉芽肿；瘙痒为核心症状，常年性发作。
Head/neck excoriations, dorsal miliary papules, symmetric abdominal alopecia, painless lip ulcers, eosinophilic plaques. Pruritus is the core symptom, typically perennial.
诊断要点
Diagnosis
主要依靠排除法，先排除跳蚤过敏、食物过敏和其他寄生虫感染；根据国际动物过敏性疾病委员会建议标准诊断。
Primarily diagnosis by exclusion — ruling out flea allergy, food allergy, and parasitic infections. Diagnosed per ICADA criteria.
研究应用
Applications
抗过敏药物、免疫调节剂、靶向生物制剂（如 IL-31 抑制剂）的临床前药效评价与安全性研究。
Preclinical efficacy and safety evaluation of anti-allergy drugs, immunomodulators, and targeted biologics (e.g. IL-31 inhibitors).
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02
猫传染性腹膜炎（FIP）
Feline Infectious Peritonitis (FIP)
FIPV Model — Type II Strain
由猫冠状病毒（FCoV）变异株引起的高致死性全身性传染病，以弥漫性血管炎和肉芽肿性炎症为特征。自研模型采用基因组测序确证的 II 型 FIPV 毒株，提供覆盖"病例入组–治疗–动态监测–出组"全周期评价体系。
A highly lethal systemic disease caused by mutant Feline Coronavirus (FCoV), characterized by diffuse vasculitis and granulomatous inflammation. Our proprietary model uses a genomically confirmed Type II FIPV strain with full-cycle evaluation from enrollment through treatment, monitoring, and endpoint.
Antiviral Drugs Vaccine Development Immunotherapy Diagnostics
模型特点
Model Features
毒株来源清晰（II 型 FIPV，基因组测序验证）；病毒滴度一致，确保批间重复性；完整 SOP 与记录体系，过程可控可溯源。
Well-characterized Type II FIPV strain (genome-sequenced); consistent viral titers ensuring inter-batch reproducibility; complete SOP documentation for full traceability.
评价指标
Evaluation Endpoints
RT-qPCR 监测病毒载量（CT>35 为转阴参考）；湿型腹腔积液及肝脾白色病灶；组织病理学炎细胞浸润与坏死；IHC 确证 FCoV 抗原。
RT-qPCR viral load monitoring (CT >35 as negativity threshold); wet-form ascites and hepatosplenic lesions; histopathological inflammation/necrosis; IHC for FCoV antigen confirmation.
血液学特征
Hematologic Profile
白细胞与中性粒细胞升高，血小板下降；总蛋白升高、白蛋白降低、球蛋白升高。
Leukocytosis with neutrophilia, thrombocytopenia; elevated total protein, hypoalbuminemia, hyperglobulinemia.
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03
猫骨关节炎（退行性关节病）
Feline Osteoarthritis (DJD)
Knee Osteoarthritis / Degenerative Joint Disease Model
以关节软骨退变、骨赘形成、骨重塑和低度非化脓性炎症为特征的关节病变。约 60% 的猫及超过 90% 的 12 岁以上老年猫存在退行性关节病，发病率最高的关节为肘关节（23.9%）和膝关节（23.9%）。
Joint disease characterized by cartilage degeneration, osteophyte formation, bone remodeling and low-grade non-suppurative inflammation. Approximately 60% of all cats and over 90% of cats over 12 years of age have DJD. Highest incidence in elbow (23.9%) and knee (23.9%) joints.
DMOAD Pain Management Joint Research Analgesics
临床特征
Clinical Features
猫跛行症状隐匿，行为变化常被误认为衰老：猫砂盆外排泄、被毛蓬乱、躲避互动、跳跃能力下降、嗜睡；体检可见脊柱后凸与关节活动受限。
Lameness is subtle in cats; behavioral changes often mistaken for aging: litter-box avoidance, unkempt coat, social withdrawal, reduced jumping, lethargy. Kyphosis and limited ROM on examination.
诊断方法
Diagnosis
主要依赖 X 线片识别骨赘、附着点骨赘、关节周围软组织肿胀和关节重塑；临床症状与影像学发现的相关性不强。
Primarily radiographic: osteophytes, enthesophytes, periarticular soft tissue swelling, and joint remodeling. Clinical signs often poorly correlate with radiographic severity.
模型类型
Model Types
自然发生模型：老年猫自发性 OA（高转化相关性）；实验诱导模型：手术干预诱导关节不稳定（用于早期机制研究与镇痛药筛选）。
Naturally occurring model: spontaneous OA in aged cats (high translational relevance); Induced model: surgical joint destabilization for early-stage mechanism studies and analgesic screening.
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04
中性粒细胞减少症
Neutropenia Model
Hematopoietic / Immunology Model
用于评价免疫调节疗法、抗感染药物及造血功能恢复的标准化模型，支持相关药物的药效学与安全性评价。
Standardized models for evaluating immunomodulatory therapies, anti-infective agents, and hematopoietic recovery. Supports pharmacodynamic and safety evaluation of relevant drugs.
Immunomodulation Anti-infective Hematopoiesis
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05
糖尿病
Diabetes Mellitus Model
Metabolic Disease Model
已建立的代谢疾病模型，适用于抗糖尿病药物评价及长期药效研究，支持胰岛素敏感性、血糖调节等多维度评价。
Established metabolic disease models suitable for the assessment of antidiabetic drugs and long-term efficacy studies, supporting multi-dimensional evaluation of insulin sensitivity and glycemic control.
Antidiabetic Drugs Metabolic Disease Long-term Efficacy
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04 — SERVICES

实验服务

Experimental Services

临床前安全性与有效性评价
Preclinical Safety & Efficacy Evaluation
PK / PD / Tox Studies
覆盖药代动力学（PK）、药效动力学（PD）及毒理学评价，为人用新药及兽用药物提供完整临床前数据包。
Comprehensive pharmacokinetic (PK), pharmacodynamic (PD), and toxicology studies delivering complete preclinical data packages for human and veterinary drug candidates.
兽用药物与疫苗检测
Veterinary Drug & Vaccine Testing
Vet Pharma · Vaccine Efficacy
以兽用药物/疫苗检测为特色，提供候选疫苗的保护力评估与免疫机制研究，支持宠物新药研发企业的注册申报需求。
Specialized veterinary drug and vaccine testing including protective efficacy assessment, immune mechanism studies, and regulatory submission support for pet pharmaceutical companies.
疾病模型建立与验证
Disease Model Development & Validation
Model Setup · SOP · Validation
建立并验证多种标准化动物疾病模型，具备完整 SOP 与记录体系，确保实验过程可控与数据可溯源。
Developing and validating standardized animal disease models with complete SOPs and documentation systems ensuring process control and data traceability.
定制化动物实验方案
Customized Animal Study Solutions
Tailored Study Design
根据客户特定需求定制实验方案，支持覆盖"病例入组–治疗–动态监测–出组"全周期闭环评价体系。
Customized study designs tailored to sponsor-specific requirements, supporting full-cycle closed-loop evaluation from enrollment through treatment, monitoring, and endpoint.
05 — ADVANTAGES

平台优势

Platform Advantages

📐
标准化操作规程
Standardized Protocols
完整 SOP 体系，严格健康监测，确保数据可靠性与重复性
Complete SOP systems and rigorous health monitoring ensuring data reliability and reproducibility
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高度转化相关性
High Translational Relevance
模型与临床兽医实践高度吻合，为新药研发提供有力支撑
Models with high relevance to clinical veterinary practice, providing strong support for drug development
⚙️
灵活定制化设计
Customizable Study Design
可根据申办方具体需求调整实验方案与评价终点
Adaptable study designs and evaluation endpoints to meet sponsor-specific requirements
06 — GALLERY

设施资质 Facility Credential

07 — CONTACT

联系我们 Contact Us

钱老师
+86 153 1278 0346
qianyujia@jianyouda.com
公司地址
Address
江苏省泰州市
中国医药城
China Medical City
Medical High-Tech Zone
Taizhou, Jiangsu